ONEbox has a clean and simple interface that’s easy to use and understand when an overdose occurs. Visual and multilingual voice instructions guide you through the entire process, from the moment you determine that help is needed, administering Naloxone, all the way through rescue breathing and briefing emergency officials.


Setting up the ONEbox is easy and quick. Everything you need is already installed. JUST ADD NALOXONE!

The ONEbox was created by Murphy Media, Inc. The ONEbox is managed by the West Virginia Drug Intervention Institute, Inc., a 501(c)(3) nonprofit organization based in Charleston, West Virginia.

Quick Start & Operational Instructions


Thank you for purchasing the ONEbox and being prepared to save lives!


The ONEbox is an emergency opioid overdose reversal and rescue kit designed to promote safety by assuring that individuals have on-demand training needed to respond to an overdose emergency through bystander intervention.


The purpose of this Standard Operating Procedure (SOP) is to provide guidance for how to install and maintain your ONEbox and its contents. We at the West Virginia Drug Intervention Institute recommend purchasers follow the procedures outlined herein to guarantee the functionality of the ONEbox.


ONEbox Checklist**

  • CPR Kit (with CPR mask, gloves, and wipes)

  • Written (readable) naloxone administration instructions

  • Scannable QR code for video instructions of Naloxone administration

  • Video component containing emergency video and training video (with option for Spanish)


**Please note that the ONEbox does NOT contain intranasal or other formulations of naloxone. The purchaser is responsible for providing this life saving medication and placing it in the box before installation following all protocols for their respective state standing order for naloxone distribution. Organizations needing advice on how to obtain free or low-cost naloxone should visit us at: or call (681) 205-2287.


DO NOT place any other items in the ONEbox except for the intranasal naloxone. Doing so could break the screen or delay the ability for emergency response.



Facility maintenance staff or a responsible individual at the participating location should be designated to install the ONEbox with the Installation Procedures outlined below.


Installation Procedures

  1. Find proper location for ONEbox

    1. Suggested are places where large groups of people tend to be or near other emergency response mechanisms. ONEbox should be easily visible and accessible, meeting all requirements of the ADA (Americans with Disabilities Act). In addition to home use, you might consider placing a ONEbox in an employee break room, behind the bar at a restaurant, on each floor of a library, or in a campus residence hall.

    2. Consider placing your ONEbox near other emergency response devices such as fire extinguishers, first aid kits, or AEDs (defibrillators) for easy access during an opioid overdose emergency.

  2. Install the ONEbox

    1. The ONEbox can be affixed to a wall (indoor use only) with nails, screws, or mounting materials appropriate to your home or facility. (Tools and parts for installation are NOT included with the ONEbox.) The ONEbox handle is designed to allow you to mount while leaving space for easy removal.

    2. You may also choose not to affix the ONEbox to a structure and instead store it in a dry, climate-controlled space.

    3. You may also choose to store the ONEbox in a vehicle. If so, we recommend that the driver remove the box daily to avoid extreme changes in temperature.


Maintenance Procedures

After installation, we recommend that one person per location is identified to fulfill the responsibilities outlined below. This could be any designated staff member, volunteer, or individual at the participating location. The point person at the location should inspect the ONEbox at least quarterly as outlined below.


Your ONEbox has shipped with a RED security tag.

The RED security tag indicates there is no product (naloxone) inside.


  1. Before placing YOUR naloxone in the box and installing it, you will want to check for functionality.

    1. Remove the RED security tag on outside of box

    2. Open the ONEbox

    3. Pull tab to activate video

      1. Emergency Response Video should engage

      2. Test training mode (press “Training Mode”)

      3. Press “Español” to determine if Spanish version is working

      4. Scan QR code and ensure that it is active and sends you to the training video (this is a redundant feature in case the video does not work at time of emergency)

    4. Check for CPR Kit containing mask, gloves, and wipes

  2. We recommend using training mode to train all staff or individuals who may need to access the box BEFORE installation and BEFORE naloxone is placed inside the box.

  3. Place your naloxone product in the box, replace the tamper evident seal (RED tag) with non-red tag (provided). This will start the quarterly expiration checking process.

  4. Each quarter, the expiration date should be checked, and the tag should be replaced indicating this has been done. Most formulations of naloxone expire between two and three years.

    1. If the naloxone is expired, you will need to replace it with additional product.

    2. If the CPR Kit needs replaced, please contact WV DII at: (681) 205-2287.

  5. If the naloxone gets used, the product must be replaced immediately, and the tag cycle should start over. The tags will need to be restocked annually by contacting us for replacements (at a small cost).


When possible, report the use of Naloxone to your local Poison Control Center. If the ONEbox point person is present at the time of the opioid overdose event, it is usually required by state or local law that they report Naloxone use. Poison Control Center: 1-800-222-1222 (Please note: Some state laws require that naloxone administration be reported can be confidential. We encourage all purchasers to review and become familiar with your state’s standing naloxone order.)



ONEbox: Opioid overdose rescue kit containing QR code for video naloxone instructions, written naloxone administration card, installation hardware, tags, and CPR Kit (mask, sterile gloves, and alcohol pad).


Naloxone: An opioid reversal medication.


Opioid: A class of drugs that work to relieve pain and can be harmful/deadly if misused. Opioids include prescription drugs (morphine, hydrocodone, oxymorphone, carfentanil, fentanyl, meperidine, tapentadol) and non-prescription drugs (fentanyl, heroin, etc.)


Opioid Overdose: This occurs when an individual consumes more of an opioid drug than their body can handle.


QR Code: A code that can be scanned via smartphone and will lead to a website.